Quorum sensing (QS) communication systems are thought to afford bacteria with a mechanism to strategically cause disease. One example is Pseudomonas aeruginosa, which infects immunocompromised individuals such as cystic fibrosis patients. The authors have previously documented that blockage of the QS systems not only attenuates Ps. aeruginosa but also renders biofilms highly susceptible to Many opportunistic pathogenic bacteria rely on quorum sensing (QS) circuits as central regulators of virulence expression. In Pseudomonas aeruginosa, QS-regulated gene expression contributes to the formation and maintenance of biofilms and their tolerance to conventional antimicrobials and the host innate immune system. Therefore, QS is an obvious target for a novel class of antimicrobial Quorum-sensing inhibitors are therefore promising candidates for anti-microbial therapy , . Natural and synthetic QS inhibitors against various molecular targets have been identified [17] – [21] and some have been shown to function in vivo, reducing mortality in animal models of bacterial infection [22] – [25] . Quorum-sensing inhibitors are therefore promising candidates for anti-microbial therapy [15], [16]. Natural and synthetic QS inhibitors against various molecular targets have been identified [17] – [21] and some have been shown to function in vivo, reducing mortality in animal models of bacterial infection [22] – [25]. The quorum sensing related genes were inhibited by phloretin. The relative transcript level of the agr system genes in quorum sensing was reduced by 50% with 20 μg/mL phloretin treatment. These findings suggest that phloretin has the potential to be developed as a natural antibacterial or biofilm inhibitor to control contamination in the food industry. Quorum sensing inhibitors: A bargain of effects. May 2006; Microbiology 152(Pt 4):895-904; DOI: 10.1099/mic.0.28601-0. QSI: a bargain of effects. 2h, u p t o 2 0 m M 3-oxo-C6 HSL can be Rasmussen TB and Givskov M: Quorum sensing inhibitors: a bargain of effects, review. Microbiology 2006; 152: 895-904. Jiang TY and Li MY: Quorum sensing inhibitors: a patent review. Expert Opin Ther Patents 2013; 23(7): 867-94. Hastings JW and Nealson KH: Bacterial bioluminescence. Annual review of microbiology 1977; 31: 549-95. Quorum sensing inhibitors: a bargain of effects. Research output: Contribution to journal › Journal article › Research › peer-review. Presentation; Citation formats; Thomas B Rasmussen; Rasmussen TB, Givskov M (2006) Quorum sensing inhibitors: a bargain of effects. Microbiology 152:895–904 PubMed CrossRef Google Scholar Reacher MH, Shah A, Livermore DM, Wale MC, Graham C, Johnson AP, Heine H, Monnickendam MA, Barker KF, James D, George RC (2000) Bacteraemia and antibiotic resistance of its pathogens reported in England and Wales between 1990 and 1998: trend analysis. Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): http://mic.microbiologyresearc... (external link)
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